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Information × Registration Number 0219U001429, 0116U007817 , R & D reports Title Receptor-mediated signaling pathways in pathobiology of chronic lymphocytic leukemia malignant cells popup.stage_title Head Sidorenko Svitlana Pavlivna, Registration Date 29-01-2019 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 In vitro studies have shown that malignantly transformed B-lymphocytes in chronic lymphocytic leukemia have different sensitivity to the effect of chemotherapy, depending on their receptor status. In the presence of CD150 expression, the cells are more susceptible to bendamustine, fludarabine and rituximab, whereas CD180 positive cells - only to fludarabine action. The obtained data substantiate the necessity of the invention to determine the status of expression of CD150 and CD180 as predictive markers of the effectiveness of chemotherapy in the treatment of patients with chronic lymphocytic leukemia. Product Description popup.authors Гордієнко Інна Михайлівна Ковалевська Лариса Миколаївна Сидоренко Світлана Павлівна Холоднюк Валерія Михайлівна Шлапацька Лариса Миколаївна popup.nrat_date 2020-04-02 Close