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Information × Registration Number 0219U001575, 0116U002404 , R & D reports Title Identify opportunities to improve high-dose chemotherapy with autologous stem cell transplantation in treatment of children with prognostically unfavorable solid malignancies popup.stage_title Head Klymniyk Grygoriy Ivanovich, Registration Date 07-02-2019 Organization Ukrainian Research Institute of Oncology and Radiology popup.description2 Object of research: 200 children with solid malignant neoplasms.The aim of the work is to improve the results of treatment of children with prognostically unfavorable solid malignant neoplasms by developing an early diagnostic methodology, identifying risk groups, and improving the methodology for high-dose chemotherapy with transplantation of autologous stem cells. Methods of research - clinical, radiation, sonographic, morphological, molecular genetic, statistical. Equipment - histo-processor Histos-5, Milestone, Italy, HM325 Thermo Scientific, Germany, flow-through cytometre 7500 Real-Time PCR Systems «Applied Bio Systems», USA, ATL HDI-5000 «Philips» USA ultrasound apparatus. As a result of the research, the factors of adverse prognosis for such forms of solid malignant neoplasms in children as neuroblastoma and Ewing's sarcoma were investigated. Clinical, morphological, morphometric, immunohistochemical and molecular genetic methods were used to determine the factors of the adverse prognosis, on the basis of which the algorithm of early intensification of treatment of children with solid malignant neoplasms was developed. The use of high-dose polychemotherapy with autologous transplantation of peripheral blood stem cells (IVCT with autoclipidemia) has significantly improved the survival rate of patients with neuroblastoma and Ewing's sarcoma. Optimal modes of conditioning of high-dose PCTs from autotocular tuberculosis in the treatment of NSC in children (Ewing's sarcoma, neuroblastoma, tumors of the brain and spinal cord, teratoblastoma) are BuMel and MES. The overall survival rate of patients is 42% (neuroblastoma) and 32.5% (Ewing's sarcoma), respectively, whereas without-10% and 27.5% of patients respectively. The introduction of the method of double (tandem) VDHT with autostocking has statistically significantly increased the non-recurrent survival rate of children with high risk neuroblast group by 8.3%. The overall survival rate of patients, which was performed only one element of VDHT with autologous TSCPC, is 51.8%, non-recurrent - 38.5%. The overall survival rate of patients undergoing dual (tandem) IVCT with autologous TSCC was 63.2%, non-recurring - 46.8%. The difference is statistically significant, p = 0,02. Product Description popup.authors Іжовський Олексій Йожефович Шайда Елен Вікторівна popup.nrat_date 2020-04-02 Close