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Information × Registration Number 0219U001833, 0115U001972 , R & D reports Title The generation of novel bioactive osteoplastic materials containig bone morphogenetic proteins for osteogenesis induction. popup.stage_title Head Korchynskyi Olexandr, Registration Date 07-03-2019 Organization Institute of cell biology, National Academy of Sciences of Ukraine popup.description2 During the forth year of work on the project we continued optimization in vitro of conditions for incorporation of mesenchymal precursor stem cells into osteoinductive matrices. We have showed that unmodified polyuretan osteoplastic materials can be optimal substrates for mesenchymal precursor cells' adhesion and modification of mentioned matrices with beta-glycerophosphate leads to local acidification of the medium. Our data will provide an opportunity to select of most effective variants of polyuretan-based biodegradable osteoplastic materials with incorporated recombinant BMP preparations, primarily BMP2/7 heretodimers, aiming to enhance their osteoinductive properties and to evaluate perpectives for their optimization with the use of antiinflammatory 4-tiazolidone derivatives along with secreted phosphoprotein 24 preparations. Such data will be an important contribution to both deeper understanding of basic molecular mechanisms in BMP signalling and practical use in translational biomedicine amd medical practice.5481 Product Description popup.authors Луцик Максим Дмитрович Стойка Ростислав Степанович popup.nrat_date 2020-04-02 Close