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Information × Registration Number 0219U003027, 0118U001346 , R & D reports Title Investigation of synthetic transformations of 3-aryl (hetaryl) isocomarines and 4 aryl (hetaryl) -2,3-benzodiazepines - the way to the creation of new biologically active substances with an effect on the central nervous system. popup.stage_title Head Khilya Volodymyr, Registration Date 15-01-2019 Organization Taras Shevchenko Kiev University popup.description2 The object of the study is N-heterocyclic products for the recycling of 3- (hetero) eryliisocomarines (2,3-benzodiazepines, isoxazoles) as promising biologically active substances. The purpose of the work is to obtain new 2,3-benzodiazepines and isoxazoles on the basis of 3- (hetero) aryl-isocoamarins and to establish the prospects for using 4- (hetero) aryl-2,3-benzodiazepines in the treatment of neurodegenerative diseases. Methods of investigation - organic synthesis, NMR spectroscopy, chromatographic mass spectrometry, rotenone model of Parkinson's disease, thin-layer chromatography, polarography, processing and analysis of experimental data. The analysis of literature data concerning the chemical modification of 2.3 benzodiazepines as a method for the preparation of new biologically active compounds was carried out. New heterocyclic derivatives of the 2,3-benzodiazepine series and new functionalized 4,5-diarylisoxazoles were synthesized. A method for the renewal of the C = N bond in 4 substituted 2,3-benzodiazepines was developed. On the example of the Rothenic model of Parkinson's disease, mitochondrial dysfunction was studied as a determining component of neurodegenerative diseases. The potential of using 4-aryl-2,3-benzodiazepine derivatives for the treatment of neurodegenerative diseases is outlined. Product Description popup.authors А.Р. Хайрулін В.В. Іщенко В.П. Хиля В.С. Москвіна Н.М. Богдан О.В. Шабликіна О.Д. Шейко С.Л. Богза Т.В. Вовкун popup.nrat_date 2020-04-02 Close