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Information × Registration Number 0219U003077, 0117U001045 , R & D reports Title Define the role of the cyclooxygenase-2 selective inhibitor along with the ionizing radiation in blocking of tumor angiogenesis for development of new technologies of the combined radiation and anti-angiogenesis therapy of oncological diseases popup.stage_title Head Mitryaeva Nataliya A., Доктор біологічних наукStarenkiy V.P., Mitryaeva N.A., Доктор медичних наук Registration Date 18-01-2019 Organization State Organization "Grigoriev Institute for Medical Radiologiy of the National Academy of Medical Sciences of Ukraine" popup.description2 Object of research: the efficiency of conformal radiation therapy in combination with cyclooxygenase-2 (COX-2) inhibitor - Ranselex in patients with non-small cell lung cancer (NSCLC) and head and neck tumors (HNT) with the determination of vascular endothelial growth factor (VEGF) levels, COX- 2 and prostaglandin E-2 (PGE-2) in blood serum. Experimental study of the effect of X-radiation and the combined effect of X-radiation and a COX-2 inhibitor - meloxivet on the content of VEGF and PGE-2. The purpose of the work is to determine the mechanisms of participation of cyclooxygenase-2 selective inhibitors in combination with ionizing radiation in blocking tumor angiogenesis to substantiate their role in radiation therapy of cancer and to develop recommendations for new technologies of combined radiation and lung cancer of the lung. Methods of research and equipment: clinical and instrumental, immunoenzymometric, electron-microscopic, dosimetric, statistical; the immunoenzymometric analyzer Immunochem-2100, sliding microtome MC-2, the universal dosimeter UNIDOS_E, the linear accelerator Clinac-600, RUM-17. Theoretical and practical results: it has been established that when using conformal radiation therapy in combination with a COX-2 inhibitor - Ranselex, a positive effect is observed in 100% of patients with HNT and in 80% of patients with NSCLC. Partial regressions prevailed, the frequency of which increased in patients with HNT and NSCLC 1.8 and 4.5 times, respectively. The mechanisms of the influence of different doses of ionizing radiation on the level of VEGF in the serum of tumor-bearing rats were determined: at a total dose of 1 Gy, stimulation of the neoangiogenesis process is observed, and at a total dose of 10 Gy, the process is slowed down. It has been proven that the combined effect of irradiation and meloxivet reduces the levels of VEGF and PGE-2 in tumor-bearing rats. Novelty: new data were obtained on the effect of the combined action of radiation therapy with Ranselex on reducing the levels of pro-angiogenic markers VEGF, COX-2 and PGE-2 in the serum of patients with NSCLC and HNT. The scientific data on the mechanisms of influence of different doses of ionizing radiation and the combined effect of radiation and the COX-2 inhibitor on the VEGF level in the blood serum of rat tumor carriers are supplemented, which is associated with the COX-2 blocking mechanism and indicates its effect on slowing down the process of angiogenesis. Domain of usage: medical radiology and oncology. Product Description popup.authors Артюх С.В. Білозор Н.В. Гребіник Л.В. Канцедал О.М. Куров О.М. Лукашова О.П. Мітряєва Н.А. Макрук О.В. Маслєннікова О.Л. Потапова Т.І. Пшишевська Л.А. Рубльова Т.В. Старенький В.П. Тесленко І.М. Ткаченко А.А. Узлєнкова Н.Є. popup.nrat_date 2020-04-02 Close