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Information × Registration Number 0219U003174, 0116U001300 , R & D reports Title Investigation of the species composition and biological properties of pathogens of wound infections in combatants in the ATO zone popup.stage_title Head Marievsky Viktor, Registration Date 24-01-2019 Organization The L.V.Gromaschevskyi Scientific and Research Institute of Epidemiology and Infectious Diseases popup.description2 Report on research work: 109 p., 21 tables, 26 figures, 105 sources. Object of research - strains UPM, isolated from the wounds of ATO participants, multiple resistance strains, isolated from stationary patients in the LPU, museum test strains, new antimicrobial drugs, commercial bacteriophages. The purpose of the study is to study the etiological structure and biological properties of pathogens of wound infections in ATO participants, to study the effects of new antimicrobial drugs Methods of research - microbiological, epidemiological, statistical, which correspond to the world level. The leading pathogens of wound infections in ATO participants were identified - K.pneumoniae (20.0%), P. aeruginosa (21.5%). Among activators of war wound infections, high resistance to all antibiotic groups was observed: 32.8 ± 5.6% of enterobacterium strains were highly resistant, 50.0 ± 7.4% P. aeruginosa and 52.8 ± 8.3% A.baumannii - pancreatic. Among S.aureus, isolated from ATO participants, a significant proportion of strains with methicillin-resistant phenotype (MRSA) was detected - 38.9 ± 11.5%. Among enterobacteria strains producing beta-lactamase of different types were found: ESBL - 40,0 ± 5,9% of strains, AmpC - 8,6 ± 3,4%; KPC - 15.7 ± 4.3% of strains; 17.1 ± 4.5% exhibited combined phenotypes. The beta-lactamase producing strains were highly resistant to clinically important antibiotic groups, beta-lactams and fluoroquinolones. Among NFGNBs, 56.5 ± 7.6% of P.aeruginosa strains and A.baumannii 69.4 ± 7.7% were MBL producers. It was found that aminoglycosides had the highest activity against the investigated enterobacteria and HFHNB-producing beta-lactamases, while the most effective drugs against specific pathogens were different depending on the phenotype of resistance. Clinical efficacy against non-strain strains of beta-lactamase is retained by carbapenems (41.2-63.9%). In 2018, we continue to monitor the prevalence of strains producing clinically important beta-lactamase types among the plurality of nosocomial infectious agents. It was found that among the studied pluripotent strains of enterobacteria, the most common types of beta-lactamases were ESBL-44,4 ± 4,3%; KPC - 25.9 ± 3.8%; AmpC - in 11.8 ± 2.8% of strains. Combined phenotypes comprised 17.2%. Among the plurality of resistant strains of NFHNB isolated from patients with surgical profile, 77.9 ± 4.5% of P. aeruginosa strains and 63.1 ± 6.0% of A.baumannii strains were MBL-producing. In the study of the antimicrobial action of the culture fluid of the fungus Piptoporus betulinus bactericidal activity against the polyresistant clinical isolates at the level of 7.8 - 48.42 mg / ml is established and is a promising raw material or an additional component for the development of antibacterial drugs. In studying the antimicrobial action of hetero-metallic compounds, it has been established that the most promising substances with activity in relation to grams of positive microorganisms are the compounds SO393, SO19, in gram-negative - Van8, SO19, SO25. The results of the work are presented in 17 articles in scientific journals, 24 theses in scientific and practical conferences, are covered in 15 reports at conferences. Published guidelines and information letter, 3 patents for the utility model, 3 applications for the invention were submitted. ANTIBIOTICOREZISTENCE, ATO, RAS INFECTIONS, BETA-LACTAMASIS, ANTIMICROBY SUBSTANCES Product Description popup.authors Вишнякова Ганна Володимирівна Гарницька Ольга Григорівна Замалєєва Катерина Петрівна Марієвський Віктор Федорович Мурашко Олена Валентинівна Петренко Олена Вікторівна Покас Олена Вікторівна Поточилова Вікторія Володимирівна popup.nrat_date 2020-04-02 Close