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Information × Registration Number 0219U003232, 0116U004757 , R & D reports Title Computer simulation and experimental study of biological nanocomposite systems. popup.stage_title Head Dragan Anatoliy, Registration Date 29-01-2019 Organization Taras Shevchenko Kiev University popup.description2 Biological nanocomposite complexes are fundamental in living systems, which makes it necessary to carry out a comprehensive analysis of the ways and mechanisms of their formation, as well as to determine the mechanisms for the inclusion of exogenous origin nanostructures into biological systems (from molecular complexes to the macro level), and to study their biological activity; the disclosure of the prospects of further industrial use, in particular, in the development of new antibacterial drugs and the direct application of nanocomposite complexes to create high-sensitivity biosensor analyzers. A significant step in understanding the scientific problem is the establishment of elemental microstructural mechanisms that determine the molecular logic of spontaneous point mutagenesis - the emergence and consolidation of inclusion and replication errors in DNA biosynthesis, and a summary conclusion is made that spontaneous point mutations are evolutionarily programmed in the electronic structure of canonical foundations DNA and hence are inevitable. By comparing the calculated data with the results of X-ray diffraction analysis, it has been shown for the first time that the irregular pair of bases with the Watson-Kryky geometry A · C and G · T are in the active center of high-precision DNA polymerase in its closed state in tautomeric forms A · C * and G * · T , which correspond to the global minimum free energy. For the first time, based on the hybrid QM / MM method of calculations and additional detailed quantum-chemical research, a picture of the interactions between SB-219383 and MtTyrRS was obtained. These results can be useful for a more effective way of creating new inhibitors of tyrosyl-tRNA synthetase in the E. tuberculosis eubacteria as prototypes of new drugs against tuberculosis. Possibility of creation of biosensors by adsorption of urease on microparticles of silicals during the creation of conductometric biosensors was checked. Product Description popup.authors І.С. Войтешенко А.І. Драган А.М. Науменко А.О. Бахмачук В.М. Заєць В.М. Пєшкова Д. Говорун Д.Ю. Кучеренко О.І. Корнелюк О.В. Солдаткіна О.В. Цимбалюк О.О. Броварець О.О. Солдаткін О.П. Солдаткін О.Ю. Нипорко О.Ю. Цуварев С.В. Дзядевич Т.Л. Давидовська popup.nrat_date 2020-04-02 Close