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Information × Registration Number 0219U003280, 0116U000759 , R & D reports Title Determination of cell surface glycan role in modulation of infections caused with adherent-invasive pathogens. popup.stage_title Head Bilyy Rostyslav Olexandrovych, Доктор біологічних наук Registration Date 06-02-2019 Organization Danylo Halytsky Lviv National Medical University popup.description2 Adherent-invasive E. coli bacteria use epithelial cells for binding and they require several dying cells for penetration. We suggested that oligomannose glycans that are exposed on the surface of dying cells and apoptotic membrane vesicles may serve as the entrance points for binding to adherent-invasive E. coli that recognize CEACAM6 receptor molecules on the epithelial cell surface. After binding of bacteria with host cells, CEACAM6 molecules form clusters on the cell surface. As soon as the bacteria penetrate into the host cell, they proliferate and colonize other adjacent cells. This lateral mobility increases their invasive capacity. Blockage or other type of elimination of oligomannose glycoepitops look as a perspective way of host invasion prevention with E. coli. Product Description popup.authors Думич Тетяна Ігорывна Луцик Максис Максимович Нич Ярина Ігорівна Парижак Соломія Ярославівна Стефанишин Юрій Михайлович Струс Христина Ігорівна Хома Ганна Володимирівна popup.nrat_date 2020-04-02 Close