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Information × Registration Number 0219U003404, 0116U002559 , R & D reports Title Design, synthesis and study of new heterocyclic compounds to create promising drugs with a wide spectrum of action popup.stage_title Head Khilya V.P., Registration Date 11-02-2019 Organization Taras Shevchenko Kiev University popup.description2 The report on the research: 175 p., 127 Figures, 4 Tables, 1 application source, 115 references. The object of study: nitrogen-, oxygen- and sulfurcontaining heterocecles. Objective: To search and develop the optimum formulations of synthesis methods for studying the structure, physical and chemical features of the new O-, S-, N-containing heterocyclic systems and carbocyclic systems with active functional groups and a wide range of performance to address the actual problems of medicine, biology, nanotechnology and photonics. Methods: Methods for the synthesis of model organic compounds, heterocyclic compounds; NMR, IR, UV, fluorescence spectroscopy; mass spectrometry and gas chromatography; Methods of synthesis at high pressure and under an inert atmosphere; X-ray diffraction and elemental analysis.The methods for the synthesis and functionalization of hetercyclic derivatives have been developed for the needs of medical chemistry, electrochemistry and photonics: (iso)coumarins, neoflavones and N-amino-isoquinolinones N-containing heterocycles; 3-thiazolylchromones, angular hetarenachromones and isochromenes; indan-1-one(ol) with natural amino acids residues; benzo[d][1,2]diazepines; a-amino-g-sultones, b-amino-g-sultams and pyrido-sultams; pyrrolysines and hexahydroindolysines; azaheterocycles, metal complexes, dyes and probes based on cyclic 2-azagetaryl-3-enaminonitriles; benzo[b]furan, 1-aminoisoindoles and pyrimido[2,1-a]isoindole; ATP probes based on 3-hydroxyflavone, Ru-NO-complexes with terpyridine ligands; pyrrolo[1,2-b]-1,2,4-triazoles, amidino(hetero)aromatic acids, fluorinated oxazole-5-carboxylic acids; isomeric 1,1-bisubstituted pyrrazolylcyclopropanes; oxidized form of dithieno-tetrathiafululvalene.The results of research are introduced in the educational process of the Faculty of Chemistry of the Kyiv National Taras Shevchenko University. Product Description popup.authors Єгорова Т.В. Бійцева А.В. Бойко О.М. Вовкун Т.В. Горбуленко Н.В. Добриднєв О.В. Кіндер Т.Д. Кисіль А.І. Левков І. В. Любчук Т.В. Максименко О.В. Москвіна В.С. Пласконь А.С. Потіха Л.М. Тарасюк Т. М. Хиля В.П. Цапко М.Д. Шилін С.В. Шокол Т.В. popup.nrat_date 2020-04-02 Close