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Registration Number

0219U003431, 0116U001533 , R & D reports

Title

Energy processes in mitochondria of cancer cells and hepatocytes under the action of azoles and furan derivatives with antitumor activity

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Head

Babsky Andriy Myroslavovych, Доктор біологічних наук

Registration Date

14-02-2019

Organization

Ivan Franko National University of Lviv

Description

The object of the study - the processes of energy supply of cancer and normal cells for the effect of chemotherapeutic drugs, as well as methods of synthesis of antitumor drugs. The subject of research - respiration and oxidative phosphorylation of mitochondria, lipid peroxidation, apoptosis, cell cycle and DNA of the influence in vitro and in vivo antitumor substances of the group of azoles (derivatives of 5-benzyl-2-aminothiazole, 1,2,3-triazole nucleus compounds ) and functionalized 2-arylfurans. The purpose of the work is the synthesis, selection and analysis of the biological effects of chemically synthesized drugs for which antitumor activity has been established but which have a minimal (side effect) effect on liver cells. Methods of research: biochemical, biophysical, polarographic, cytological. Among the derivatives of 5-benzylthiazoles promising were two substances that were cytotoxic in their cytotoxicity or even more effective than doxorubicin in relation to cells of glioblastoma and melanoma. One of the drugs not only at the level with doxorubicin caused the death of T cells in acute leukemia, but also stimulated the processes of programmed cell death (apoptosis), damage to the cell cycle delay in the G1 phase. It was established that one of the mechanisms for the implementation of cytotoxic effects of thiazole derivatives and furans may be the accumulation of products of peroxide lipid oxidation and decrease of activity of antioxidant enzymes in cancer cells.

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Бабський Андрій Мирославович
Гренюх Володимир Петрович
Луців Тимофій Геннадійович
Мандзинець Світлана
Манько Володимир Васильович
Матійчук Василь Степанович
Остап’юк Юрій Володимирович
Фінюк Наталія Степанівна
Шалай Ярина Романівна