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Information × Registration Number 0219U003450, 0116U001675 , R & D reports Title Physico-chemical characteristics and functions of ligand forms of hemoglobin in pathologies of different etiology popup.stage_title Head Sybirna Natalia Olexandrivna, Registration Date 14-02-2019 Organization Ivan Franko National University of Lviv popup.description2 The results expand and complement the understanding of biochemical mechanisms mediating changes in the physical, chemical and functional state of hemoglobin at alcohol intoxication (AI) and diabetes mellitus (DM). The paper substantiates the role of the processes of nitrosation and nitrosylation of hemoglobin in the development of metabolic disorders in the conditions of the studied pathologies. It was found that the changes in the erythron system in experimental AI in rats are characterized by: a decrease in the effectiveness of erythropoiesis; an increase in the number of degenerative forms of red blood cells and the number of physiologically old cells. Intake of L-Arg rats with AI helped to restore the level of discocytes to normal values. The consumption of animals L-NAME had no effect on the cytological parameters of cells in the peripheral blood of rats in control and experimental AI. Comparative studies of the absorption spectra of hemoglobin in the control and after incubation of erythrocytes with spirocarbon were carried out. In healthy donors and patients with DM I type, the addition of spirocarbone to peripheral blood erythrocytes leads to a delay in the onset of hemolysis and an increase in the proportion of resistant erythrocytes. It is shown that incubation of erythrocytes with compounds that contain a derivative pyrrolopyrimidine does not affect the ratio of particles of the basic ligand forms of hemoglobin. Product Description popup.authors Єфіменко Наталія Валентинівна popup.nrat_date 2020-04-02 Close