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Information × Registration Number 0219U003588, 0116U003568 , R & D reports Title Optimization of methods of treatment of patients with non-alcoholic steatohepatitis in persons exposed to ionizing radiation, on the basis of the correction of metabolic changes and supression persistent infections. popup.stage_title Head Chumak Anatoliy Andreevich, Ovsyannikova Ludmila Mihailovna, Registration Date 29-01-2019 Organization State institution "National research centеr for radiation medicine of the National academy of medical sciences of Ukraine " popup.description2 The effectiveness of treatment of non-alcoholic steatohepatitis (NASH) in the victims of the Chernobyl accident has been investigated, with the evaluation of changes in the activity of the herpesvirus infection, the antioxidant system(AOS) and the functional state of the liver. It was established that the preparations based on aminoacids significantly improved the functional state of the liver, fat and carbohydrate metabolism, reduced the processes of lipoproxidation, increased the activity of the antioxidant system with the normalization of the AOS factor, the titres of antibodies to the Epstein-Barr virus antibody were reduced by anti-EBV EA IgG, and anti-EBV NA IgG . Treatment with hepatoprotectors and antioxidant aevit increased the activity of enzymes of the antioxidant system (superoxidedismutase, catalase), the integral index of AOS; improved liver status according to ultrasound and biochemical parameters of blood with a decrease in cholestasis, hypercholesterolemia, hyperglycemia, did not affect the increased lipid peroxidation. After treatment, the titres of herpes simplex virus antibodies, cytomegalovirus. Antiviral therapy in the complex treatment of NASH in the victims of the ChNPP accident reduced the activity of the cytolytic syndrome, the incidence of cholestasis (p <0,05), hypercholesterolemia (p <0,05), with an increase in AOS with (1534 ± 237) of the standard units to (2117 ± 431) standard units, in 58,3% of patients anti-HSV-1/2 IgG titres were reduced, in 54,5% of cytomegalovirus patients, 36,3% were Epstein-Barr rind, 33,3% of cases of nuclear antibodies. Product Description popup.authors Альохіна С.М. Кадюк О.М. Носач О.В. Плескач О.Я. Саркісова Е. О. popup.nrat_date 2020-04-02 Close