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Information × Registration Number 0219U003592, 0116U003572 , R & D reports Title Neyropsyсhobiological mechanisms of the mood and cognitive disorders in the exposed persons as a result of the Chernobyl disaster considering polymorphisms of genes. popup.stage_title Head Loganovsky Konstantin, Registration Date 29-01-2019 Organization State institution "National research centеr for radiation medicine of the National academy of medical sciences of Ukraine " popup.description2 Purpose: the definition of neuropsychiatric, psychophysiological, neuropsychological features of cognitive and affective disorders and gene polymorphisms in the survivors after the Chernobyl accident in the remote period of irradiation. The object of the research is the clean-up workers after the ChNPP accident, irradiated in utero as a result of the Chernobyl accident and unexposed control. In the clean-up workers after the ChNPP accident dominated cerebrovascular diseases, organic mental and depressive disorders mainly radiation-stressor. The overall risk of neuropsychiatric pathology increases (Pv <0.001) with the dose of irradiation. The revealed psychoneurological symptoms in irradiated prenatal cases as a result of the Chernobyl disaster largely corresponds to the criteria of the syndrome of chronic fatigue (cognitive variant). This syndrome may be the debut of another, more severe neuropsychiatric pathology. Violent verbal memory and training, reduced IQ due to verbal, both in ULNA and prenatally irradiated persons. Increased frequency of mild cognitive impairment and dementia. Cognitive impairment at doses> 0.3 SV depend (r = 0.4-0.7; P = 0.03- 0.003) on the dose of irradiation. Affective disorders (depression) and neurocognitive deficits are higher at higher doses of irradiation (>50 mSv). In the left posterior temporal region (Vernicke zone), the EEG parameters depend on the dose at irradiation in doses greater than 0.25-0.3 Sv. Disturbed information processes of the brain with lateralization to the Vernicke zone already at doses> 50 mSv. Carriers of intermediate and low-level genotypes (LA/S, LA/LG, LG/LG, LG/S, S/S) of serotonin transporter gene SLC6A4 have more depressive disorders, especially severe, and tend to be more frequent and severely cognitive and stressful. The debut of depressive disorders in carriers of intermediate and low-function genotypes occurs much earlier (Log-Rank Test = 4.43, P = 0.035) compared to carriers of high-performance genotype LA/LA. Radiation-induced dysfunction of the cortico-limbic system of the left dominant hemisphere of the brain with a special involvement of the hippocampus is the key cerebral basis of organic brain damage after irradiation. The association of genotypes with 5-HTTLPR and rs25531 polymorphisms of the SLC6A4 gene with affective and cognitive disorders suggests the presence of neuropsychobiological features of these disorders associated with ionizing radiation, depending on certain gene polymorphisms. Product Description popup.authors Абраменко Ірина Вікторівна Антипчук Катерина Юріївна Білоус Н.І. Бомко Марія Олександрівна Гресько Марина Володимирівна Крейніс Георгій Юрійович Куц Костянтин Володимирович Логановська Тетяна Костянтинівна Масюк Сергій Вікторович Нечаєв С.Ю. Перчук Ірина Вадимівна Чумак Станіслав Анатолійович popup.nrat_date 2020-04-02 Close