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Information × Registration Number 0219U004542, 0114U001279 , R & D reports Title Posttranslational changes (modification) of proteins under pathological processes. popup.stage_title Head Brazaluk Olexsandr Zacharovih, Registration Date 03-09-2019 Organization State organization "Dnepropetrovsk medikal akademy of Ministry Health Ukraine" popup.description2 It was found, that the the glycanes of alpha 1-acid glycoprotein and fibronectin are changed in patients with the proliferative blood diseases and the character of these changes determines the type and severity of the disease. The redistribute of glycotopes on the plasma membrane of the lymphocyte was found after the chemotherapy. It is found that changes of the activity of matrix metalloproteinases and serine proteinases in plasma of the patients characterize the severity of the pathological process. The spectrum of free oligosaccharides in human plasma change in cardiovascular diseases, and these changes depend on the type and severity of myocardial damage. Cardiovascular diseases are associated with the development of carbonyl-oxidative stress and increase of oxidative modification of proteins. It was confirmed that activation of proteolysis and oxidative modification of proteins are triggered under conditions of experimental myocardial ischemia. The use of antioxidants and some cardioprotectors decrease the oxidative modification of proteins and that is the one part of their therapeutic effects. Product Description popup.authors Абраімова Ольга Євгенівна Бразалук Олександр Захарович Гордієнко Юлія Анатоліївна Долгіх Ганна Віталіївна Маслак Ганна Сергіївна Нетроніна Ольга Володимирівна Письменецька Ірина Юріївна Ткаченко Вікторія Андріївна Шаульська Ольга Едуардівна Шевцова Алла Іванівна popup.nrat_date 2020-04-02 Close