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Information × Registration Number 0219U004557, 0116U004984 , R & D reports Title Factors of formation , the progression of different clinical phenotypes of bronchial asthma, COPD and community-acquired pneumonia: peculiarities of the course, comorbid conditions, prediction and prevention popup.stage_title Head Ospanova Tetyana, Registration Date 05-09-2019 Organization 3.Kharkov national medical university popup.description2 The study for and the development of optimal measures for the diagnosis and treatment of patients with bronchial asthma (BA), chronic obstructive pulmonary disease (COPD) and community-acquired pneumonia (CAP) are relevant at present. BA, COPD and CAP occur in 20-15% of the adult population, more than 50% of this cohort of patients have comorbidity. Multicomponent changes in the body, taking into account the decrease in immunoreactive factors, the presence of genetic prerequisites, the effect of viral infections, the use of antibacterial agents that cause changes in the resistance of the upper and lower respiratory tract. Along with this, quite often these nosological forms are found in combination with other somatic diseases, due to which different phenotypes of these diseases can be distinguished. Thus, the development of criteria for diagnosis, monitoring and prediction, the features of the therapeutic strategy and improving the quality of life of patients with various clinical phenotypes of bronchopulmonary pathology (BA, COPD and CAP) is currently relevant. We evaluated the content of TC and its fractions, IL-6, IL-8, immunological status, sputum bacterioscopy, microprecipitation reaction, content of DNA-diagnosis, evaluation of the polymorphism of the ACE gene and the eNOS gene, FEV, PEF, and ECHO-CG. Thus, the analysis of changes in the above indicators allowed to identify the phenotype of COPD with decreased renal function, the eosinophilic phenotype and the phenotype of COPD with metabolic syndrome. Along with this, features of the mechanisms of formation of induced secondary immune deficiency with the involvement of the immune cell line and the autoimmune component of inflammation in patients with BA in combination with obesity and type 2 diabetes mellitus (DM) have been identified, affecting the degree of control and contributing to a more severe course of the disease. At least four risk factors have been detected in patients with severe hepatitis B, including: bad habits, severe social status, late treatment, no treatment at the pre-hospital stage, concomitant pathology, namely, type 2 DM, hypertension, COPD and chronic heart failure. Chronic persistence of herpesvirus infection, which is one of the factors of suppressing cellular immunity, contributes to the severe course of CAP. In the presence of cellular immunodeficiency in patients with anemia, there is a connection between the immunodeficiency and the pathogen of the disease, with a greater probability of being due to pneumococcus, enterobacteria, haemophilus influenzae. Product Description popup.authors Єрьоменко Галина Володимирівна Авдєєва Ольга Володимирівна Більченко Ольга Сергіївна Бабічева Олександра Олександрівна Бездітко Тетяна Василівна Борзенко Алла Борисівна Веремієнко Ольга Василівна Красовська Катерина Олексіївна Піонова Олена Миколаївна Семидоцька Жанна Дмитрівна Трифонова Наталія Сергіївна Хіміч Тетяна Юріївна Чернікова Ірина Олегівна popup.nrat_date 2020-04-02 Close