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Information × Registration Number 0219U004569, 0116U004979 , R & D reports Title Chemical-pharmaceutical and experimental substantiation of pharmacological propertiesof oxicams and their compositions with caffeine popup.stage_title Head Syrova Ganna O., Registration Date 05-09-2019 Organization 3.Kharkov national medical university popup.description2 The quantum-chemical studies of oxycam molecules (piroxicam and meloxicam), caffeine and their compositions, and experimental studies on the comparative characteristics of analgesic (peripheral and central genesis), anti-exudative, antipyretic effects, and their effect on the content of sialic acids and C-reactive protein in the blood of rats (biochemical study), on the CNS for emotional-behavioral reactions in the conditions of formalin edema. The spatial, energy, and electronic characteristics of the molecules of piroxicam and meloxicam have been established using Quantum Structure Activity Relationship (QSAR) methods of quantum chemistry. The analysis of the results of experimental studies indicates that the addition of caffeine to oxicamam increased the anti-exudative activity, reduced inflammatory marker values (sialic acids and C-reactive protein), analgesic activity (central and peripheral genesis), but piroxicam - only of central genesis. Addition of caffeine to piroxicam promoted an increase in the antipyretic activity of piroxicam, normalization of the cognitive activity of rats, positively influenced the grooming, stimulation the amount of urination. Additin caffeine to meloxicam contributed to an increase in vertical motility, the amount of defecation, the normalization of cognitive activity in rats. The paper provides a quantum-chemical and experimental justification for the feasibility of creating new domestic two-component pharmaceutical compositions (piroxicam + caffeine and meloxicam + caffeine) with anti-exudative and analgesic action and can be recommended for further study. Product Description popup.authors Завада Оксана Олександрівна Каліненко Ольга Сергіївна Козуб Світлана Миколаївна Краснікова Юлія Миколаївна Левашова Ольга Леонідівна Лук'янова Лариса Володимирівна Макаров Володимир Олександрович Петюніна Валентина Миколаївна Савельєва Олена Валеріївна Синельник Вячеслав Володимирович Тішакова Тетяна Станіславівна Чаленко Наталія Миколаївна popup.nrat_date 2020-04-02 Close