Search academic texts

Information × Registration Number 0219U005298, 0118U005323 , R & D reports Title Development of prototypes of antiepileptic drugs - modulators of the brainstem of the brain. popup.stage_title Head Maximyuk Oleksandr Petrovych, Registration Date 30-07-2019 Organization Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine popup.description2 Using the electrophysiological method of measurement, 25 compounds were investigated and the 15 most promising chemotypes were determined. The therapeutic and pharmacological characteristics of 8 optimized active drug candidates for therapeutic agents have been etermined - in different models of epilepsy in vitro. All active molecules did not exhibit toxic effects when administered intracranial to the ventricles of the brain of experimental animals. Physico-chemical and ADME / Tox characteristics of optimized active compound candidates for medicinal products were obtained. Product Description popup.authors Єгорова Олена Володимирівна Ісаєв Дмитро Сергійович Кришталь Олег Олександрович Хмиз Володимир Васильович Чернінський Андрій Олександрович popup.nrat_date 2020-04-02 Close