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Information × Registration Number 0219U005469, 0114U007006 , R & D reports Title Analysis of epidemiology risk of development of the dizregulatory states and comorbid pathology factors at chemistry drug-resistant tuberculosis and way of their overcoming. popup.stage_title Head Matsegora Nina Anatoliivna, Registration Date 26-11-2019 Organization Odesa National Medical University popup.description2 Results - in patients with DRTB and co-infection DRTB/HIV/AIDS damage of internal organs occurs by different pathogenetic mechanisms, which requires a differentiated approach to the treatment of these patients. In patients with DRTB in a terminal state biochemical parameters exceed the physiological level by 1.3 times. While in patients with co-infection DRTB/HIV/AIDS there is an increase in the levels of total bilirubin (1.5 times the norm) due to the direct fraction (6 times the norm), a twofold increase in the activity of serum transaminases, dyslipidemia (lipoprotein levels were almost 2 times higher than normal) and dysproteinemia (thymol test was 6 times higher than normal), which explained the accumulation of nitrogenous slags: urea (8.56 ± 0.98 mmol/L), residual nitrogen (34.77 ± 5.3 mmol/L) and creatinine (186 29 ± 26.58 ?mol/L). The appointment of immunoglobulin G in the complex treatment of patients with DRTB/HIV helped to reduce the manifestations of anemia by reducing the toxic load on the hematopoiesis and normalizing white blood counts with a decrease of the clinical manifestations of intoxication, which allowed prescribing ARVT and prevent the development of systemic inflammation in patients with DRTB/HIV with severe immunosuppression (CD4 + <200). Product Description popup.authors Бєсєда Ярослав Віталійович Бабуріна Олена Анатоліївна Капрош Антоніна Вікторівна Лекан Оксана Ярославівна Мацегора Ніна Анатоліївна Омельян Лариса Павлівна Полякова Світлана Олександрівна Смольська Ірина Миколаївна Шпота Олена Євгенівна popup.nrat_date 2020-04-02 Close