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Information × Registration Number 0219U005488, 0115U006647 , R & D reports Title The State of the microcirculative-tissue, cell and endocrine factors in endometrial and placental complex hyper- and hypoplastic processes and etiopathogenic directions of their correction and therapy popup.stage_title Head Zelinskiy Alexandr Alexeevich, Registration Date 26-11-2019 Organization Odesa National Medical University popup.description2 Hyperplastic endometrial processes, atypical hyperplasias are characterized by balance disorders between proliferation and apoptosis processes, with worsening apoptotic activity dynamics at atypical forms background. The atypical endometrial hyperplasia development is accompanied by ER expression general decrease both at stroma and endometrium on the background of PR more significant decrease in comparison with their level in general endometrium at all EH.Recurrent endometrial hyperplasia on the background of ЕR and PR misbalance, Ki67 proliferative activity increase along with p53, bcl-2 figures, which characterized apoptotic activity processes decrease, connected with endometrial oncological transformation high risk like consequences of mitogenic and mutagenic hormonal genesis effects and progressing mutational damage with hormone-independent local growth. The proper time decision for the surgical treatment need to be done at that women cohort.For the hyperplastic endometrial processes diagnostics quality improvement and therapeutic tactics prospective determination to the general morphological examination ER and PR receptors concentration and hyperplastic processes proliferation and apoptosis markers immunohystochemical determinants Ki67, P53, bcl-2 must be included. Product Description popup.authors Артьоменко Володимир Вікторович Гладчук Василь Ігорович Дерішов Василь Володимирович Дерішов Сергій Васильович Ермоленко Тетяна Олексыъвна Жовтенко Олеся Вікторівна Зелінський Олександр Олекса ндрович Зубаренко Костянтин Олександрович Кожухар Ганна Володимирівна Манасова Гульсим Сирикбаевна Мніх Людмила Володимирівна Надворна Ольга Миколаївна Настрадіна наталія Миколаївна Ходорчук Костянтин Васильович Чумак Зінаїда Василівна Шаблій Тетяна Петрівна Шаповал Микола Віталійович popup.nrat_date 2020-04-02 Close