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Information × Registration Number 0219U005627, 0114U000909 , R & D reports Title Biophysical mechanisms of metastability physiological state of cells undergoing ionotropic and metabotropic actions popup.stage_title Head Korogod Sergiy M., Registration Date 26-12-2019 Organization Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine popup.description2 Models of excitatory cells of various types and ion channels, which are expressed by them, were developed. On the basis of the analysis of structure-dependent dynamic metastable electric states, patterns of the discharge of action potentials (AP), general and type-specific features of cellular activity pattern formation were revealed. The general features were the relationship between synaptic activation, electrical asymmetry, dynamic states of dendrites, and the AP patterns. The type-specific were the membrane conductivity ranges, which corresponded to the greatest electric asymmetry and the most complex patterns. It has been established that hypothermic inhibition of burst discharges of hippocampal neurons expressing thermo-sensitive TRP channels can be one of the mechanisms of the therapeutic effect of hypothermia. It is shown that in the neonatal motor neurons, the slow inactivation of Kv1.2 channels is critical for the formation of bistable states, which ensure the transition from rest to locomotion. A special role of the basal current of the mechano-sensitive channels in the formation of metastable depolarization states of the receptor zone of mechanonociceptors was revealed. These and Nav1.9 channels can generate abnormally increased basal input currents in abnormal conditions. In the model of the myenteric afferent neuron, it was discovered that the Nav1.9 current determines the duration of the metastable depolarization state of depolarization and plays the role of a molecular switch between the modes of generation of single and bursting APs, which is an important factor in regulating the motility and secretion in the intestine. It is shown that the Ca2+-dependent Cl-current essentially determines the parasympathetic excitation of the bladder detrusor cells, and the reduction of their parasympathetic excitation under m-cholinoreceptor deficits can be compensated by an increase in P2X conductivity under the action of purinomimetics. Product Description popup.authors Демяненко Л. Е. Каспіржний А. В. Корогод С. М. Коченов А. В. Кулагіна І. Б. popup.nrat_date 2020-04-02 Close