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0219U005628,
0116U004470
,
Biophysical and molecular-genetic mechanisms of regulation of physiological and pathological processes
Krishtal Oleg Oleksandrovych,
26-12-2019
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine
Using the paired patch-clamp technique, we studied the effects of short-term hypoxia on АМРА-mediated retinocollicular synaptic transmission in an originally-developed coculture of dissociated retinal cells and superficial superior colliculus (SSC) neurons. Pharmacologically isolated AMPA?mediated postsynaptic currents were evoked in SSC neurons by generation action potentials in presynaptic retinal ganglion cells. Short-term (up to 5 min) hypoxia induced temporary suppression of AMPA transmission. Evoked postsynaptic currents were analyzed in terms of a binomial model. This analysis revealed that hypoxia-induced temporary suppression of AMPA transmission is the result of presynaptic dysfunction (decrease in release probability and in average number of release sites). The results obtained reflect the electrophysiological basis of hypoxia-involved pathological lesion of the retinocollicular pathway.
Є. Забенько
Є.В. Кравенська
Є.В. Моісеєнко
Є.О. Нікандрова
І.І. Ченцова
І.Б. Філіпов
І.В. Лушнікова
І.М. Маньковська
І.О. Осадченко
І.Ю. Охай
А. Драмарецький
А.В. Горковенко
А.В. Мазниченко
А.В. Савотченко
А.Г. Портниченко
А.Г. Степанюк
А.Л. Борисюк
А.М. Сидоренко
А.М. Шиш
А.Ю. Лучкова
Б.Р. Шаропов
Б.С. Коп'як
Березовський В.Я.
Блашків Т.В.
В.Є. Досенко
В.І. Носар
В.І. Портніченко
В.А. Горбаченко
В.А. Мітрузаєва
В.А. Яворський
В.В. Корнєєв
В.В. Кротов
В.Г.Найдьонов
В.П. Яценко
В.С. Нагібін
В.Ф. Сагач
Вознесенська Т.Ю.
Г.В. Думанська
Г.В. Портніченко
Г.В. Соткіс
Г.Г. Скибо
Грушка Н.Г.
Д.Є. Дужий
Д.О. Пашевін
Д.О. Строй
Е. Шеремет
Е.В. Багацька
К. Агашков
К.В. Розова
К.Г. Сможанік
К.Л. Гулак
К.О. Драчук
Кондрацька О.А.
Л.І. Колчинська
Л.А. Мись.
Л.В. Тумановська
Л.М. Шаповал
Л.П. Мельничук
Л.С. Насібян
Літовка І.Г.
Левашов М.І.
М. Краснякова
М.І. Василенко
М.А. Пацева
М.В. Телька
М.С. Шипшина
М.С.Веселовський
Н.І. Кононенко
Н.А. Струтинська
Н.В. Булгакова
Н.В. Войтенко
Н.М. Разумна
Н.О. Богданова
Н.О. Дорофієва
О. Рибачук
О.І. Бондаренко
О.І. Костюк
О.І. Костюков
О.В. Єгорова
О.В. Акопова
О.В. Грищенко
О.В. Довгань
О.В. Рихальський
О.Г. Ніконенко
О.Е. Пурнинь
О.Е. Сафтенку
О.М. Бакуновський
О.М. Цупіков
О.О. Гончар
О.О. Кришталь
О.О. Лук'янець
О.П. Колесник
О.П. Любанова
О.П. Максимюк
О.П. Маньківська
П.В. Білан
П.П. Майоренко
Павлович С.І.
Р.А. Федічкіна
Р.Б. Струтинський
Р.О. Моргачов
С.А. Федулова
С.В. Войтенко
С.В. Гончаров
Сафонов С.Л.
Т.І. Древицька
Т.А. Ільїна
Т.А. Півнева
Т.В. Серебровська
Т.М. Коваленко
Т.Ю. Лапікова_Бригінська
Чака О.Г.
Ю.Б. Дискіна
Ю.В. Гошовська
Ю.М. Коляда
Ю.П. Коркач
Я.М. Шуба
Янко Р.В.
Янчій Р.І.
Яценко К.О.
2020-04-02
Updated: 2025-12-07
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