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Information × Registration Number 0219U005631, 0114U007233 , R & D reports Title Investigation of mechanisms of myocardial remodeling in the pathogenesis of heart failure and its correction popup.stage_title Head Dosenko Viktor Yevgeniyovych, Registration Date 26-12-2019 Organization Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine popup.description2 The decrease of microRNA 210 in SHR and Wistar rats during aging was established. At the same time microRNA 155 was not changed with the age. Experiments with rat neonatal cardiomyocytes have revealed significant increase of the microRNA 210 level under the HIF 3 alpha gene knockdown mediated by shRNA-interference. The level of microRNA 155 was not changed significantly at the same conditions. The decrease of the MMP 2 and MMP 9 activities in old rats subjected to ?-3 PUFA enriched diet was also revealed. Human and rats microRNAs that could inhibit expression of ATP-dependent potassium channels expression (KCNJ8, KCNJ11, ABCC8 and ABCC9) were determined. The proteasomal inhibitor Quercetin has been shown as an effective preventive factor of neutrophil extracellular traps formation at the myocardial ischemia-reperfusion modeling in rats. Product Description popup.authors А.М.Шиш А.С. Жуковська В.Є.Досенко В.С.Нагібін Г.В. Портніченко Д.О. Строй Д.О.Пашевін З.О. Серебровська Л.В.Тумановська М. Хецуріані О.С. Панасюк Р.Б.Струтинський Р.О. Моргачов С.В. Гончаров Т.І. Древицька Т.О. Козак Т.Ю. Лапикова-Бригінська popup.nrat_date 2020-04-02 Close