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Information × Registration Number 0219U005636, 0119U003180 , R & D reports Title Exploration of the role of mitochondria in responses of cardiovascular system at different functional states of an organism popup.stage_title Head Sagach Vadym Fedorovych, Registration Date 26-12-2019 Organization Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine popup.description2 It is shown that course introduction of cofactor of H2S-synthesizing enzymes of pyridoxal-5P led to stimulation of synthesis of endogenous hydrogen sulfide (H2S) in aging, suppressed Ca2 + -induced opening of MP (mitochondrial pores), reduction of oxidative and nitrozative stress and heart function of old animals after ischemia-reperfusion. In addition, a cardioprotective reaction was observed with the introduction of endothelial monocyte activating protein EMAPII and its structural precursor (p43), which significantly increased the efficiency of oxygen use by ischemic myocardium and also inhibited the opening of MP at reperfusion. It is shown that impaired diastolic and contractile function of the left ventricle occurs in the modeling of focal cerebral ischemia, and the introduction of a donor of H2S sodium hydrosulfide (NaHS) or a substrate of its synthesis L-cysteine in the nuclei of the dorsomedial department of the medulla oblongata of the rat brain was accompanied with hypothensive reaction. Product Description popup.authors І.Ю.Охай А.І.Бондаренко А.Ю.Лучкова Б.С. Коп"як Богданова Н.О. Бурлак М.П. Бурлак О.П. В.Ф. Сагач Врублевський С.В. Горбаченко В.А. Дробная О.Е. Ж.О Крученко К.О.Драчук Кравенська Є.В., Л.А.Мись Л.М. Шаповал Лук'янець І.О Лук'янець О.О. Магура І.С. Мельник І.В., Н.А. Струтинська Н.О. Дорофєєва О.В. Акопова О.В.Дмитренко Петрушенко М.О. Петрушенко О.А. Р.А.Федічкіна Т.А. Ільїна Тарасенко О.М. Ченцова І.І. Шкриль В.М. Ю.В.Гошовська Ю.П.Коркач Яворський В.А., popup.nrat_date 2020-04-02 Close