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Information × Registration Number 0219U006208, 0117U002579 , R & D reports Title The role of peptidergic structures of hypothalamus and brain stem in the pathogenesis of arterial hypertension. popup.stage_title Head Kolesnуk Yuriі Mikhailovуch, Registration Date 24-04-2019 Organization Zaporozhye State Medical University popup.description2 On the basis of the conducted experimental research it was proved, that hereditary arterial hypertension in the SHR line rats is accompanied by a significant increase in hypothalamic neurons morpho-functional activity.Analysis of the nitrogen monoxide system state in the studied structures demonstrated that hereditary arterial hypertension in the SHR line rats leads to changes of the NOS enzyme isoforms expression in the arcuate nucleus of the hypothalamus. The study of the content of brain neurohormones which influence the vascular tone has shown that hereditary arterial hypertension in SHR rats, results in a significant reduction in the content of brain natriuretic peptide, beta endorphine and angiotensin along with a significant increase in neurotensin expression in the arcuate nucleus of the hypothalamus. In the neurons of the vagus nerve dorsal complex and brain stem locus coeruleus arterial hypertension leads to a decrease of depressor neuropeptides (beta-endorphin, lei-met-enkephalin) parameters of expressions. Product Description popup.authors Іваненко Т.В. Ісаченко М.І. Абрамов А.В. Ганчева О.В. Данукало М.В. Мельникова О.В. Тіщенко С.В. popup.nrat_date 2020-04-02 Close