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Information × Registration Number 0219U006212, 0112U005635 , R & D reports Title Research of biopharmaceutical, pharmacokinetical and reological properties of applique medicinal forms with the matters of different pharmacological action popup.stage_title Head Gladyshev Vitaliy Valentinovich, Доктор фармацевтичних наук Registration Date 24-04-2019 Organization Zaporozhye State Medical University. Department of psychiatry popup.description2 Based on complex technological, physico-chemical, biopharmaceutical, rheological, microbiological and pharmacological studies, scientifically substantiated and experimentally validated formulations and technology of highly effective and stable application forms of amlodipine and enalapril maleate (rectal suppositories, cream and nasal gel) for cardiological practice . The physicochemical, technological, microbiological and biopharmaceutical properties of developed amlodipine and enalapril maleate (rectal suppositories, cream and gel nasal) have been studied and methods of their standardization have been proposed. Conditions of storage, temperature regime, stability and expiration dates of developed compositions have been studied. On the basis of pharmacological studies, the specific activity was experimentally established and the biological harmlessness of the developed application soft molds of amlodipine and enalapril maleate for rectal and nasal administration was proven. Product Description popup.authors Гладишев Віталій Валентнович Гладишева Світлана Анатоліївна Кечин Ігор Леонідович Количева Наталія Леонідівна Лисянська Ганна Петрівна Нагорний Володимир Володимирович Пухальська Ірина Олександрівна popup.nrat_date 2020-04-02 Close