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Information × Registration Number 0219U006214, 0113U005084 , R & D reports Title The search of synthetic, physicochemical and biological activities of the derivatives of 5-aryl,-heteryl-4amino-1,2,4-triazole-3-thiones popup.stage_title Head Kaplaushenko Andriy Grygorovich, Доктор фармацевтичних наук Registration Date 24-04-2019 Organization Zaporozhye State Medical University. Department of psychiatry popup.description2 Preparative methods for the synthesis of 5-aryl, heteryl-1,2,4-triazol-3-thion derivatives are developed. More than 300 new compounds were synthesized as potential biologically active substances. Acute toxicity, antimicrobial, antifungal, actoprotective, antihypoxic, antioxidant, antipyretic, diuretic, hypoglycemic, cardioprotective and neuroprotective activities were studied, which allowed selecting more than 50 biologically active compounds that exceed the reference preparations, as well as revealing previously unknown links between the presence and nature of substituents and biological action. For 2 (5- (3,4,5-trimethoxyphenyl) -1,2,4-triazol-3-ylthio) hydrogen chloride acetamide, 3- (4-nitrophenyl) -5- (nonylsulfonyl) -1,2,4 -triazole-4-ammonium hydrochloride and 2 - ((4-ethyl-5 (phenoxymethylene) -4H-1,2,4-triazol-3-yl) thio) acetate hydrochloride the drafts of laboratory synthesis procedures, technical requirements relative to the final product, as well as the quality control methods (QCM) were developed and approved Product Description popup.authors Гуліна Юлія Сергіївна Каплаушенко Андрій Григорович Кучерявий Юрій Миколайович Самелюк Юрій Геннадійович Щербак Марина Олексіївна popup.nrat_date 2020-04-02 Close