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Information × Registration Number 0219U100103, 0116U000501 , R & D reports Title "Study of the role of genetic component to occupational chronic obstructive pulmonary disease" popup.stage_title Head Basanets Anzhela V., Доктор медичних наук Registration Date 24-01-2019 Organization Government agency "Institute of Ocupational Health named by Y.I. Kundiev of National Academy of Medical Sciences of Ukraine" popup.description2  It was defined the frequency of genotypes of MMP-2, a2M, ELN genes in coal miners with COPD and in healthy miners. The association was revealed for the minor genotypes and geterozygotes: MMP-2*TT, MMP-2*СT, a2M*Val/Val with the risk of development of COPD occupational etiology . Genotypes associated with resistance for COPD are next: MMP-2* CC, a2M*IIe/IIe і a2M*IIe/Val. There were no significant differences in the frequency of genotypes of the ELN gene in the examined miners. It was determinated 59 different combinations of alleles of the genes: MMP-2, TIMP-2, а2M, ELN. It was revealed that 4 genotypes MMP9*СС,MMP2*CC,TIMP2*G/G,a2M*IIe/IIe,ELN*Gly/Gly; MMP9*СС,MMP2*CТ,TIMP2*G/G,a2M*IIe/Val,ELN*Gly/Gly; MMP9*СС,MMP2*CС,TIMP2*G/G,a2M*IIe/Val,ELN*Ser/Se; MMP9*СТ,MMP2*CC,TIMP2*G/G,a2M*IIe/IIe,ELN*Gly/Ser are associated with resistance to COPD in underground coal miners. Genotypes MMP-9*СС,MMP-2*CC,TIMP-2*G/А,а2M*IIe/Val,ELN*Gly/Ser are associated with the risk of development to COPD in the population of coal miners in Ukraine. The recommendations on improving of prevention system of оcupational COPD. Product Description popup.authors popup.nrat_date 2020-04-02 Close