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Information × Registration Number 0219U100240, 0116U000332 , R & D reports Title The determination of biochemical and functional disorders that cause sexual dimorphism of major cardiovascular risk factors of type 2 diabetes mellitus popup.stage_title Head Gorbenko Nataliya I., Доктор біологічних наук Registration Date 31-01-2019 Organization State Institution “V.Ya.Danilevsky Institute of Endocrine Pathology Problems of Academy of Medical Sciences of Ukraine” popup.description2 Object: Type 2 diabetes, male and female rats, cardiovascular risk factors, functional status and oxidative status of cardiomyocytes mitochondria, endothelial dysfunction markers, cardiovascular and haemocoagulation systems. The purpose: to determine the sexual dimorphism of the diabetic cardiovascular complications pathogenesis based on the identification of risk factors (dysglycemia, dyslipidemia, obesity, pro-inflammatory and procoagulation status, oxidative stress, endothelial dysfunction and mitochondrial dysfunction of cardiomyocytes). Methods of research: pathophysiological, biochemical, electrophysiological, statistical. It was established that type 2 diabetes mellitus in rats more significant increases of glucose intolerance, insulin resistance, hypertriglyceridemia, and the level of total lipids in the liver of males compared to females. Type 2 diabetes increased more significant the level of lipid peroxidation products and decreased the total antioxidant activity of blood serum, which was accompanied by a more pronounced oxidative stress in the heart of diabetic males compared with females. Type 2 diabetes activates the antioxidant defense system in rat mitochondria in females and suppressed it in males. Type 2 diabetes more significantly decreases the activity of aconitase and succinate dehydrogenase in the heart mitochondria and activates of non-specific mitochondrial pores (mPTP) in males. It was shown that type 2 diabetes is accompanied by more pronounced disorders of the system of coagulation haemostasis and the development of myocardial diastolic dysfunction in females. The results indicate the perspectives of new methods development for prevention and treatment of diabetic cardiovascular complications.The area of results use: health care, clinical and experimental diabetes.  Product Description popup.authors popup.nrat_date 2020-04-02 Close