Search academic texts

Information × Registration Number 0219U100271, 0115U002945 , R & D reports Title Target-specific search of aminoacyl-tRNA synthetases inhibitors with selective action against agents cause human infections diseases. popup.stage_title Head Tukаlo Mykhаilo A., Доктор біологічних наук Registration Date 04-02-2019 Organization Institute of Molecular Biology and Genetics of NAS of Ukraine popup.description2 We have performed virtual screening of compound collection, containing 124829 ligands into active site of seryl-tRNA synthetase Staphylococcus aureus using molecular docking program - DOCK4.0. Accordingly to the results of docking calculations and visual inspection of the complexes of ligands with active site of seryl-tRNA synthetase S. aureus we selected 300 compounds for investigation of their inhibitory activity toward recombinant enzyme in vitro. We have obtained recombinant seryl-tRNA synthetase S. aureus with the purity > 95%.  Product Description popup.authors popup.nrat_date 2020-04-02 Close