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Information × Registration Number 0219U100301, 0118U003796 , R & D reports Title Molecular mechanisms of inflammatory chronic pain.Then second year of impiementation. popup.stage_title Head Voitenko Nana V., Доктор біологічних наук Registration Date 05-02-2019 Organization Department for special training National academy of science of Ukraine at Kiev University popup.description2  It has been shown that the mean frequencies and the amplitudes of spontaneous excitatory synaptic events in retrogradely identified spino-pontine neurons of lamina I in isolated preparations obtained from rats with peripheral inflammation were significantly higher than the respective parameters in control units. Such increased excitability of neuronal networks in the dorsal horn in general and in projection neurons of lamina I in particular can provide a significant contribution to the development of hyperalgesia related to chronic inflammatory states and to facilitation of generation of pain-related emotions. It has been shown that nucleoids obtained from the neurons display the kinetics of DNA exit that is typical for cells with high transcriptional activity. The DNA loops were approximately three-times decreased in neurons obtained from rats with peripheral inflammation. Product Description popup.authors popup.nrat_date 2020-04-02 Close