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Information × Registration Number 0219U100309, 0118U003793 , R & D reports Title Properties, mechanisms of regulation and functional role of systems of passive and energy-dependent transport of Ca ions in the smooth muscle cells..Then second year of impiementation. popup.stage_title Head Kosterin Sergiy O., Доктор біологічних наук Registration Date 05-02-2019 Organization Department for special training National academy of science of Ukraine at Kiev University popup.description2  The aim of the project is to elucidate the molecular and membrane mechanisms of ionized Ca concentration regulation in the smooth muscle cells. It was shown that permeabilized myometrium cells incubation with calix[4]arenes containing two or more chalcone amide groups, accompanied by an increase in the level of myometrial mitochondria membranes polarization. All studied calix[4]arenes increased [Ca2+]m values in the absence and in the presence of exogenous Ca2+. It was also shown that isolated mitochondria incubation with studied calix[4]arenes resulted in changes of mitochondria volume: average hydrodynamic diameter decreased at incubation with С-1012, С-1021, C-1023 and increased with С-1011. It was shown that C60 fullerenes are vasoconstrictors and, accordingly, they inhibit the activity of BKCa channels and L-type voltage-gated calcium channels, but not the voltage-gated potassium channels (KV), which suggests the selectivity of these modulators, and therefore they can be considered as promising pharmacological correction tools of a vascular tone. Electrophysiological and tensometric recordings indicate the functional expression of TRPV4 channels in the smooth muscle cells of the pulmonary arteries and their important role in vasoregulation by membrane depolarization, as well as the possible functional interaction of TRPV4 channels with L-type voltage-gated calcium channels (VGCC-L) during the calcium ions entering in the vascular smooth muscle cells. Product Description popup.authors popup.nrat_date 2020-04-02 Close