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Information × Registration Number 0219U100775, 0116U002690 , R & D reports Title Studying the pharmacological and therapeutic effectiveness of biologically active substancess of natural origin to correct pathogenetic disorders in eyeball contusion (experimental study) popup.stage_title Head Sotnikova Olena P., Доктор медичних наук Registration Date 13-03-2019 Organization State Institution "The Filatov Institute of Eye Disease and Tissue Therapy of NAMS of Ukraine" popup.description2 A combination of instillations and periocular injections of Lipoflavon and a combination of instillations of Lipoflavon and periocular injections of the yellow sweet clover extract for blunt trauma of the eye were found to have a pronounced pharmacological effect based on clinical signs of the total post-traumatic response of the eye. A subtenon Lipoflavon injection decreased the total post-traumatic response of the eye as compared to a subconjuctival injection of Lipoflavon. Instillations and subtenon injections of a liposomal quercetin-based drug for experimental blunt trauma of the eye were proved to have pronounced membrane-stabilizing and antioxidant actions, to normalize glycolysis and a content of lipid peroxidation products in the tear fluid and blood serum. The most pronounced positive effect on the metabolic process was noted in the rats which received simultaneously instillations and subtenon injections of Lipoflavon. Therapeutic instillations of Lipoflavon in a combination with Lipoflavon subconjunctival or subtenon injections for experimental blunt trauma increase protein synthesis and energy production in eye tissues, which is evidenced by elevated levels of polysomes, free ribosomes, and mitochondria. Therapeutic instillations of Lipoflavon eyedrops in a combination with subconjunctival or parabulbar yellow sweet clover extract injections for experimental blunt trauma result in an increased level of organelles which are involved in protein synthesis (free ribosomes and polysomes), which decreases alterative processes and swelling in eye tissues. Product Description popup.authors Sotnikova Olena P. Чуднявцева Наталія Олександрівна Lotosh Tamara Dmitrivna Abramova Ganna Saldan Viktoria Fesyunova Ganna popup.nrat_date 2020-04-02 Close