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Information × Registration Number 0219U100926, 0117U004833 , R & D reports Title Development of biocompatible implants of bone tissue and skin and use of electromagnetic radiation of optical range of spectrum for optimization of processes of regeneration. popup.stage_title Head Korobov Anatolii M., Registration Date 03-04-2019 Organization V.N. Karazin Kharkiv National University popup.description2 The aim of this project is to develop biocompatible implant bone and skin that have the ability to biorezorbtsiyi and stimulation of reparative regeneration in the body of the recipient, and explore the impact of electromagnetic radiation in the optical range of the spectrum (EMVODS) on the quality of their regeneration in experiment and in clinic. As a result of the second phase of the authors conducted a study of patterns of electromagnetic radiation in the optical range of the spectrum (EMVODS) processes of dehydration and sterilization of implants that are allowed to develop technology extension of their period of use. Methods of impregnation (saturation) of implants with photosensitizers (dimecin, photon) were developed, which have antibiotic properties when activated by means of EMWS; promising drug compounds (nano-crystalline cerium dioxide) and mesenchymal stem cells (MSCs). When impregnation implants, scaffolds mesenchymal stem cells were used irradiation with red light spectrum range, which significantly increased the proliferative and adhesion properties of MSCs. Different lesions of bone and skin (diarrhea, circular) were modeled on experimental animals. Experimental models for evaluating the joint implantation of implants and EMWODs were developed for animal immunoreactivity with tissue damage data. Research was carried out on the direction and degree of changes in the segments of immunoreactivity after the combined application of implants and EHVODS on animal models. Immunophenotyping of MSCs, which were implanted with EWVOD, was performed by flow cytometry. The following indices of developed and applied on animal models of implants such as adhesion, endocytosis of phagocytic cells, the ability to create active forms of oxygen by these cells, the degree of cytotoxicity of serum components, and the intensity of the creation of antigen + complexes were studied and evaluated using light and immunofluorescent microscopy and immunoassay methods. antibody +  Product Description popup.authors popup.nrat_date 2020-04-02 Close