Search academic texts

Information × Registration Number 0219U101203, 0118U004551 , R & D reports Title Grid and Virtual Organization CSLabGrid as powerful search tool for of new antimitotic compounds effective against Golden staph popup.stage_title Head Blume Yaroslav B., Доктор біологічних наук Registration Date 29-05-2019 Organization Institute of Food Biotechnology and Genomics of the National Academy of Sciences of Ukraine popup.description2  The improved model of FtsZ protein Staphylococcus aureus, the main protein of a bacterial mitotic vehicle, was constructed. Based on the results of a chemo-analytical search using the reference substance PC190723 and Tanimoto70 criteria, 156,686,000 commercially available compounds were selected and a library suitable for further virtual screening using VO CSLabGrid was created. According to the results of high-throughput molecular screening, docking, molecular modeling and molecular dynamics in Grid, promising inhibitors (22 substances) of the mitotic fragmentation of Staphylococcus aureus were selected. Product Description popup.authors Demchuk Oleh M. Karpov Pavlo A. Ozheredov Sergey P. Rayevsky Olexey V. Samofalova Dariya O. Spivak Svitlana I. popup.nrat_date 2020-04-02 Close