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Information × Registration Number 0219U101461, 0115U001358 , R & D reports Title The development of biotechnological wound coverings for application in medicine popup.stage_title Head Lukash Lyubov Leonidivna, Доктор біологічних наук Registration Date 05-08-2019 Organization Institute of Molecular Biology and Genetics of NAS of Ukraine popup.description2 In the third stage, using two animal models, it was found that cell xenografts are effective as dermal coverings in the treatment of thermal burns of IIIb grade. The most pronounced therapeutic effects were obtained using live human 4BL line cells (multipotent mesenchymal stromal cells) and A102 line cells (skin fibroblasts). Mechanisms of regenerative effect are probably mediated by products that cells release into the culture medium during cultivation. The high efficiency of cell-free preparations containing a complex of biologically active substances secreted by cells during of their vital activity in vitro is shown. The most effective for the healing of burn wounds among all studied preparations was a one based on a medium conditioned by 4BL cells. Product Description popup.authors popup.nrat_date 2020-04-02 Close