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Information × Registration Number 0219U102002, 0115U005147 , R & D reports Title Synthesis, study of structure and physico-chemical properties of calix[4]arenes popup.stage_title Head Rodik Roman V., Кандидат хімічних наук Registration Date 12-12-2019 Organization Institute of Organic Chemistry NAS of Ukraine popup.description2 For the first time, a conjugate of diaminocalix[4]arene was synthesized with biophoric fragments of a well-known non-steroidal anti-inflammatory agent, mefenamic acid. Investigation of its structure by various methods has shown that amide bonds are spatially available both for interaction with target glycoproteins and for peptidase enzymes that can release mefenamic acid.Bis-mefenamidocalixarene exhibits high anti-exudative activity Comparison of the specific anti-exudative activity of dimephenamidocalixarene and the starting mefenamic acid indicates a significant advantage of calixarene derivative Product Description popup.authors Yesypenko Oleksandr A. Vyshnevskiy Sergiy G. Cherenok Sergiy O. popup.nrat_date 2020-04-02 Close