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Information × Registration Number 0219U102015, 0119U102244 , R & D reports Title Design, synthesis, and directed chemical transformations of heterocyclic compounds of a series of azoles and azines. popup.stage_title Head Sorochynsky Oleksandr Е., к.х.н. Registration Date 13-12-2019 Organization V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine popup.description2 The literature data on the synthesis and chemical properties of β-alkoxyvinyl trifluoromethyl ketones were summarized. In order to obtain new trifluoromethyl-containing unsaturated cyclic ketones, trifluoroacetylation reactions of 4-methylene-1,3-dioxolanes were studied. New cyclic trichloro- and trifluoromethyleneones with an additional masked -hydroxymethyl group were synthesized. The reactivity of the obtained compounds in reactions with nucleophiles was investigated. Procedure for the preparation of enaminones with an additional -hydroxymethyl group in high yields has been developed. Various enaminones have been obtained; an equilibrium and relative content of Z/E isomers have been investigated depending on the polarity of the solvent. The interaction of trifluoro- and difluoromethyleneones with hydrazine in acetonitrile was shown to be an effective approach to 3-trifluoromethyl- and 3-difluoromethylpyrazole with an additional hydroxymethyl group in 75-77% yield. The reaction of new cyclic trifluoromethylenones with water has been investigated and the products of hydrolysis formed by intramolecular cyclization were obtained. The oxidation of trifluoro- and difluoromethyl-containing pyrazoles with an additional hydroxymethyl group to the corresponding aldehydes and carboxylic acids was developed. The transformations of trifluoro- and difluoromethyl-containing pyrazoles with an additional hydroxymethyl group into the corresponding fluoromethyl derivatives in reaction with sulfur tetrafluoride are studied. Product Description popup.authors Bugera M. Ya. Gerus Ihor I. Zhuk Yu. I. Shaitanova Olena M. popup.nrat_date 2020-04-02 Close
R & D report
Design, synthesis, and directed chemical transformations of heterocyclic compounds of a series of azoles and azines.
Head: Sorochynsky Oleksandr Е.. Design, synthesis, and directed chemical transformations of heterocyclic compounds of a series of azoles and azines.. (popup.stage: ). V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine. № 0219U102015
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Updated: 2026-03-21


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