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Information × Registration Number 0219U102027, 0119U103217 , R & D reports Title Molecular design of 9,10-anthraquinone derivatives - prototypes of new anticancer agents popup.stage_title Head Zvarych Viktor I., Registration Date 13-12-2019 Organization Lviv Polytechnic National University popup.description2 Studies on predicting the antitumor activity of hydrazone derivatives of 9,10-anthraquinone have been carried out. A convenient method for the preparation of various hydrazone derivatives of 9,10-anthraquinone with alkyl, carbo- and heterocyclic, amidoxime fragments in the ylidene part of the molecule has been shown. Experimental study of antitumor activity revealed promising compounds with a cytostatic effect against the cancer cell line of leukemia (K-562, SR), breast cancer (MCF7, T-47D, MDA-MB-468), kidney (ACHN, A498), thick intestines (HCT-116, COLO 205), ovaries (IGROV1) and non-small cell lung cancer (NCI-H522, EKVX).  Product Description popup.authors Stasevych Maryna V. popup.nrat_date 2020-04-02 Close