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Information × Registration Number 0219U102346, 0119U101624 , R & D reports Title Synthesis, spectral-luminescent properties of new alkylamino-beta-ketoenol compounds and metal complexes based on them to produce fluorescent probes of biomolecules and optical materials popup.stage_title Head Pekhno Vasyl I., Доктор хімічних наук Registration Date 26-12-2019 Organization V.I. Vernadskii Institute of General & Inorganic Chemistry NAS of Ukraine popup.description2  A series of novel amino-β-ketoenol dyes with various aromatic substituents were investigated and studied as probes for the fluorescence detection of amyloid protein aggregates. Depending on the nature of the substituents, these dyes increase the emission intensity by up to 60-fold in the presence of fibrillar aggregates, while being less sensitive to native proteins. Sensitivity to amyloid aggregates depends on both the amino group substituents and the nature of the aryl groups. The effect of tetraphenyl porphyrins, including amino and carboxy substituted, on amyloid aggregation of insulin was studied. The most pronounced effect on the kinetics of the reaction of insulin aggregation was found for tetra (4-carboxyphenyl) porphyrin - a decrease in the intensity of insulin aggregation by about 90%. Product Description popup.authors Ilnytska Olena L. Dovbii Yan M. Kovalska Vladyslava B. Losytskyy Mykhaylo Yu. Tretyakova Irena M. Tsaryk Natalia V. Chernii Viktor Ya. popup.nrat_date 2020-04-02 Close