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Information × Registration Number 0220U000146, 0117U003038 , R & D reports Title Studying the role of intestinal mikrobiom in the development and progression of obesity, insulinresistance and diabetes popup.stage_title Head Tkach Sergiy M., Registration Date 17-01-2020 Organization Ukrainian scientifical-practical centre of endocrine surgery, endocrine organs and tissues transplantation of Ukrainian Ministry of Health popup.description2 For the first time in domestic practice, the quantitative and qualitative composition of the intestinal microbiota and the ratio of its major philotypes in obesity, insulin resistance and diabetes were studied, and their relationship with the severity and compensation of type 2 diabetes is shown. The results of the study indicate that with increasing severity and decompensation of diabetes, a progressive decrease in the total number of Bacteroidetes was observed, as well as an increase in Firmicutes and an F / B ratio. For the first time in Ukraine it has been shown that in patients with obesity and IP there is a decrease in the quantitative level of Bifidobacterium spp. and Lactobacillus spp. (respectively, 87.8% and 75.8% of patients), as well as active contamination of the intestine with different species of Enterobacter spp., and patients with diabetes mellitus 2 have a significant decrease in the quantitative level of Bifidobacteriumspp. (81.3% of patients), Lactobacillusspp. (71.9% of patients), as well as increase of quantitative indices of damage of intestines by conditionally pathogenic gram-positive cocci, such as S. aureus and S. epidermidis, mushrooms of the genus Candida and esherihs with changed biological properties, such as E. coli (heme +) and lactose-negative. For the first time in Ukraine, the incidence of CNSD in the small intestine in obesity and type 2 diabetes has been investigated and it is shown to be a significant pathogenic risk factor for NAFLD / NASH in patients with obesity, insulin resistance and type 2 diabetes. It has been shown for the first time that the use of rifaximin and multicomponent probiotics is an effective treatment for NAFLD / NASH in the presence of SNBR. The results obtained allow to improve the timely detection of intestinal dysbiosis in patients with diabetes, to optimize approaches to the choice of individual therapy of such patients, to reduce hospitalization cases in wards due to the deterioration of their health, to reduce the cost of budget and own medical expenses, to improve social and psychological adaptation of patients. The results of the study can be applied in the clinical work of endocrinologists, surgeons, family doctors at all levels of care. Product Description popup.authors Юзвенко Т.Ю. popup.nrat_date 2020-04-02 Close