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Information × Registration Number 0220U000250, 0117U003027 , R & D reports Title To study the role of circulating microribonucleic acids in the control of metabolic and immunoinflammatory factors of atherogenesis in patients with the combination of ischemic heart disease and type 2 diabetes mellitus. popup.stage_title Head S. Serik, Registration Date 24-01-2020 Organization Government Institution "L.T.Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine" popup.description2 The study involved 90 patients with coronary heart disease with type 2 diabetes and 77 patients without diabetes, 32 healthy people. Research methods: clinical and instrumental, assessment of carbohydrate metabolism and blood lipid spectrum, markers of inflammatory activation, determination of miRNA-27a, -221 levels; vasculoendothelial growth factor; gene expression of PPAR ? receptors. It was established that with the combination of IHD with diabetes, a specific decrease in the levels of circulating miRNAs 27a and - 221 occurs. The connection of these miRNAs with glucometabolic disorders, the formation of diabetic dyslipidemia, inflammatory activation, and dysregulation of angiogenesis is proved. It was shown that miRNA-27a can serve as a predictor of cardiovascular events, and its low level should be used as an additional criterion for choosing the dose and type of statins. Product Description popup.authors Бондар Т.М. Бугріменко Г.П. Воронова Н.І. Горб Ю.Г. Зоренко Н.В. Комір І.Р. Костюк О.І. Мороз О.С. Оврах Т.Г. Оклей О.В. Рябуха В.В. Сердобинська-Канівець Е.М. Стороженко Т.Є. Строна В.І. Ткаченко О.В. Ченчик Т.О. popup.nrat_date 2020-04-02 Close