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0220U000252,
0117U003029
,
To develop the methods of prevention of hypertensive heart's progression for patients by hypertensive disease with obesity on the basis of molecular-genetic, humoral and structural-functional factors studies.
S. Koval,
27-01-2020
Government Institution "L.T.Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine"
240 patients with hypertension with and without obesity were examined. Research methods: general clinical, instrumental, biochemical, molecular genetic. A new mechanism for the development and progression of hypertensive heart in obese hypertensive patients has been established - a decrease in the production of powerful antihypertrophic and antifibrogenic factors, an epigenetic factor, miRNA-133a, and growth differentiation factor-11. A method has been developed to prevent the progression of hypertensive heart in these patients, taking into account the molecular genetics and humoral regulators of hypertrophy and fibrogenesis.
Божко В.В.
Зоренко Н.В.
Кірієнко М.В.
Корнійчук І.А.
Костюк О.І.
Любчіч Г.М.
Милославський Д.К.
Мисниченко О.В.
Пенькова М.Ю.
Снігурська І.О.
Старченко Т.Г.
Щенявська О.М.
Юшко К.О.
2020-04-02
Updated: 2025-12-07
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