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Information × Registration Number 0220U000428, 0117U004303 , R & D reports Title "To study the mechanisms of adaptation of the heart after surgical, endovascular and electrophysiological methods of the treatment of hypertrophic cardiomyopathy" popup.stage_title Head Kostyantyn Rudenko, Registration Date 11-02-2020 Organization M.M.Amosov National Institute of Cardio-Vascular Surgery of the Academy of Medical Sciences of Ukraine popup.description2 Research report "To study the mechanisms of cardiac adaptation after surgical, endovascular and electrophysiological methods of treatment of hypertrophic cardiomyopathy": 174 pages, 5 sections, 24 tabs, 63 fig., 393 sources. Key words: obstructive form of hypertrophic cardiomyopathy, septal myectomy, resection of pathological (secondary) chords, mobilization of papillary muscles, alcoholic septal ablation, fibrosis, electrophysiological properties of myocardium, speckle-tracking echocardiography. Objective: To study the mechanisms of cardiac adaptation after endovascular, electrophysiological, and surgical treatments to improve quality and life expectancy of patients with hypertrophic cardiomyopathy. As a result of the work: - first described in detail the changes in deformation, longitudinal displacement and rotation of the left ventricular myocardium in patients with HCM, features of myocardial morphology in patients with HCM before and after alcoholic septal ablation; - Direct and distant hemodynamic and morphometric results after alcoholic septal ablation and Ferrazzi surgery were investigated; - the feasibility of conducting alcoholic septal ablation and single-stage coronary artery stenting in patients with HCM and concomitant coronary heart disease; - scientifically proven improvement in the quality of life of patients with OGCMP who underwent alcoholic septal ablation or Ferrazzi surgery; - the effect of dual antiplatelet therapy on hemodynamic results after alcoholic septal ablation in patients with HCM and concomitant coronary heart disease was studied; - found that with GCMP pathology of the mitral valve flaps manifests a significant increase in their size relative to the end-diastolic index of the left ventricle; - 278 surgical interventions were performed for patients with GCMP according to the new surgical technique; - protocol of pre-operative diagnostics of patients with HCMP was developed and a fundamentally new method of surgical treatment of patients with HCMP; - created a database of patients with HCMP who underwent surgery and alcoholic septal ablation; - the estimated survival of patients within 10 years after alcoholic septal ablation and Ferrazzi surgery; - determined the practical advantage of surgical treatment by the new method in patients with obstructive HCM over other existing methods of treatment. Product Description popup.authors Буряк Р.В. Гнилорибов А.М. Гринь К.В. Кравчук Б.Б. Матяш О.Р. Невмержицька Л.О. Федьків С.В. Чижевська О.О. popup.nrat_date 2020-04-02 Close