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Information × Registration Number 0220U000429, 0118U005478 , R & D reports Title To determine the prognostic significance of intercellular interaction mediators and differentiation clusters of substrate cells for stratification and optimization of the myelodysplastic/myeloproliferative neoplasms treatment popup.stage_title Head Nataliia Tretiyak, Registration Date 11-02-2020 Organization Kiev Research Institute of Haematolojy and Blood Transfusion popup.description2 Object of study: 27 patients with myelodysplastic / myeloproliferative neoplasms in the initial period and after treatment with immunomodulatory or hypomethylating drugs. The immunophenotypic profile of bone marrow tumor cells was determined by flow cytometry. Indicators of the potential expression of CD34 +, CD34 + / CD117 + differentiation clusters on cells of myeloid lineage have been shown to be factors potentially evaluating treatment response, prognosis of MDS / MPN progression, and resistance to therapy. It has been shown that the aberrant immunophenotype of BM cells of myeloid origin in MDS / MPN is one of the markers of tumor progression and can be an immunological criterion for predicting the course of the disease and stratifying patients according to the risk groups for MDS / MPN progression and also for treatment. Medical and social effect. The medicine. Product Description popup.authors Андреєва С.В. Білько Н.М. Басова О.В. Гордієнко А.І. Кубарова В.О. Стародуб Г.С. Третяк Н.М. popup.nrat_date 2020-04-02 Close