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Information × Registration Number 0220U000659, 0119U000226 , R & D reports Title Rational design of S,N-modified aminothiols as potential anti-radiation agents. popup.stage_title Head Kornet Maryna, Registration Date 10-09-2020 Organization Zaporozhye National University popup.description2 The object of the scientific work: potential radioprotectors - S-heterylmodified derivatives of endogenous thiols. The purpose of the research work is to develop promising substances with antioxidant and potential radioprotective properties capable of blocking and / or reducing the effects of radiation. The idea of the project is the modification of the well-known protectors of this group (endogenous thiols - cysteamine, cysteine) by nitrogen-containing heterocycles to reduce toxicity, prolonging their action by slowing their metabolism and reducing the necessary doses for the protective effect. In the performance of this study, the available primary materials, saved by research protocols, scientifically proved all results and photographing, the correctness of the results obtained was sufficiently sampled and analyzed by statistical methods of analysis. Useful practical and methodological developments are a combinatorial library of compounds with potential radioprotective properties, were developed methods for their synthesis. In the presented scientific study, the first stage includes the study only in silico format. The results of this study indicate that the compounds selected for synthesis have the potential to outperform prototypes - cysteamine (the first open radioprotector) and cysteine by antioxidant activity, which is the basis of one of the mechanisms of radioprotective action, and they also exhibit lower toxicity rates. A more detailed and objective analysis of the different features will be in the next steps in vitro and in vivo. As a result of the first stage of scientific work the following results were obtained: I. A combinatorial library of compounds with potential antioxidant and radioprotective properties has been developed. II. Virtual screening of compounds with potential radioprotective properties using PASS prediction and QSAR analysis. III. Methods for the synthesis of selected compounds are developed. Product Description popup.authors Євлаш (Амінова) Аліна Сергіївна Амінов Руслан Флузович Богдан Анна Михайлівна Бражко Олена Олександрівна Завгородній Владислав Михайлович Карпун Євген Олександрович Кривко (Ткаченко) Алевтина Ігорівна Лагрон Аліса Вадимівна Мурликіна Марина Володимирівна Романенко Яна Ігорівна Сільванович Олександр Олексійович popup.nrat_date 2021-03-17 Close