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Information × Registration Number 0220U000676, 0117U006446 , R & D reports Title Efficacy, cardio- and gastrointestinal safety of immunosuppressants and calcium antagonists of the dihydropyridine series when combined in a model of rheumatoid arthritis combined with arterial hypertension popup.stage_title Head Seredinskaya Nataliya Nikolaevna, Доктор медичних наук Registration Date 02-11-2020 Organization State Institution "Institute of Pharmacology and Toxicology of National Academy of Medical Sciences of Ukraine" popup.description2 The analgesic and anti-inflammatory effects of the Leflunomide immunosuppressant when combined with Amlodipine under conditions of adjuvant arthritis associated with hypertension have been investigated. The result of work on the analgesic effect of Leflunomide testifies to its effectiveness against the background of comorbid pathology. Amlodipine enhances analgesic activity when combined with Leflunomide, which justifies the use of a calcium antagonist to enhance the analgesic effect of Leflunomide when required as its primary indication (as an antihypertensive agent). Independent administration of Leflunomide does not lead to the manifestation of an anti-edematous effect on the background of combined pathology, while Amlodipine promotes the manifestation of an anti-edema effect of Leflunomide when combined. These results make it possible to optimize the ways of choice of medicines of these pharmacotherapeutic groups and to improve the medical technology of treatment of comorbid conditions, in particular - arterial hypertension accompanying or arising on rheumatoid arthritis. Product Description popup.authors Акімова Н. В. Бершова Т. А. Киричок Л. М. Марченко О. М. Матвієнко А. В. Мохорт Н. А. Серединська Н. М. Суворова О. С. Хоменко В. С. popup.nrat_date 2021-03-17 Close