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Information × Registration Number 0220U000686, 0117U006445 , R & D reports Title Optimization of structures of potention bioactive compounds whih analgesic and antiinflammatory in series of condensed Azol- and Azino-containing heterocyclics popup.stage_title Head Demchenko Anatoliy Michajlovich, Seredinska Natalia Mykolayvna, Registration Date 02-11-2020 Organization State Institution "Institute of Pharmacology and Toxicology of National Academy of Medical Sciences of Ukraine" popup.description2 According to the results of experimental in vivo studies, a number of triazolo-azepines and imidazo-azepines isolated leaders, their structural modification and virtual screening for the likelihood of analgesic and anti-inflammatory activity. 14 new triazolo-azepine derivatives were synthesized, and their pharmacological testing was performed in the tests "hot plate", "acetic acid seizures" and "carrageenan edema". The synthesized compounds showed pronounced antalgesic action. It is proposed for molecular modeling of 4 triazolo azepine derivatives and 2 imidazo-azepine derivatives. Product Description popup.authors Баглай Олександр Юрійович Бершова Тетяна Анатоліївна Бобкова Людмила Станіславівна БухтіароваТетяна Анатоліївна Голубов Михайло Іванович Демченко Сергій Анатолійович Дудник Андрій Євгенійович Козир Віталій Анатолійович Козлик Валерій Васильович Лук янчук Віктор Дмитрович Марченко Олена Миколаївна Суворова Олександра Сергіївна Хайрулін Андрій Рашидович Хоменко Василь Станіславович popup.nrat_date 2021-03-17 Close