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Information × Registration Number 0220U100078, 0118U005185 , R & D reports Title Development of 2D-materials and "smart" sensors for medical and biological purposes on their basis. Section 3. 2D-materials based on BN and WS2 as potential antitumor and antimetastatic agents popup.stage_title Head Соляник Галина Іванівна, Registration Date 09-01-2020 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine popup.description2  It was conducted the primary screening of the cytotoxic/cytostatic action of 2D-nanomaterials based on boron nitride (BN), its modifying form (BNm), and molybdenum sulfide (MoS2) against tumor cells independence of their concentration and incubation time. In this work LLC cells, the parental high metastatic counterpart was used as an experimental tumor model. It was established that 2D-nanomaterials based on boron nitride and molybdenum sulfide in concentrations studied demonstrated a low cytotoxic activity against LLC cells, which did not potentiate in case of increase of long-term incubation. As applied to their use in the combination with the anticancer drug doxorubicin mentioned 2D-nanomaterials at least did not significantly decrease the efficacy of cytotoxic action of anticancer drugs against tumor cells. This indicates the possibility of using nanomaterials in combination with anticancer drugs in vivo, for example as a carrier device. Product Description popup.authors Kolesnyk Denys L. Piaskovska Olga M. Solianyk Galyna I. popup.nrat_date 2020-04-02 Close