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Information × Registration Number 0220U100118, 0117U000096 , R & D reports Title Synthesis of heterocyclic nitrogen and organo-phosphorus compounds and research of their biological activity. popup.stage_title Head Вовк Андрій Іванович, Registration Date 10-01-2020 Organization V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine popup.description2 A new preparative method for the synthesis of 1-alkyl-3-methyl-1,4-dihydropyrazolo[4,3-c]pyrazoles has been developed, which is simple to perform and has good reproducibility. Substituted 5-amino-1H-imidazole-4-carbonitriles were synthesized, and new (5-imino)imidazolidin-2-one derivatives were obtained, that are of considerable interest as potentially biologically active substances. Organo-lithium compounds were received from 2-bromo-4-(1,3-dioxolan-2-yl)-1,3-thiazole, which was shown to interact with electrophiles to produce new trifunctionally substituted 1,3-thiazole derivatives. A number of new 4.7-functionally substituted representatives of pyrido[2,3-d]pyrimidine by the reactions of intramolecular cyclization of the condensation products of the available pyrimidine-5-carbaldehydes have been synthesized. A simple, fast and economical one-reactor method for the preparation of novel 6-aminopyrido[2,3-d]pyrimidine-7-ones by reaction of 4-amino-substituted pyrimidine-5-carbaldehydes with methyl N-(4-methoxybenzylidene)glycinate is proposed. Methods of enzymatic separation using lipase Burkholderia cepacia obtained optically pure 1,2-cis- (S, R) -azidoaminocyclopentane, the catalytic hydrogenation of which provided a vicinal diaminocyclopentane. The possibility of using the α-ketophosphonate derivatives of calix[4]arene as light-controlled inhibitors of protein tyrosine phosphatases on examples of PTP1B and MEG2 was evaluated. The O-acyl-substituted vitamin B1 derivatives and isoflavone-based hybrid compounds with pyrrolopyridine fragment were studied as inhibitors of cholinesterases. The azomethine derivatives of p-aminobenzoic acid were studied as potential antioxidants and inhibitors of xanthine oxidase. The data on auxin-like activity of a number of heterocyclic compounds at the level of control of the morphology of the root system of Arabidopsis thaliana plants in vitro were obtained. Product Description popup.authors Ivanova Irina V. Abdurakhmanova Esma R. Biletska Іryna M. Biletsky Igor І. Brovarets Volodymyr S. Buldenko Vladyslav M. Bukhonska Yaroslava К. Veligina Yevheniia S. Verves Evgeniy V. Vydzhak Roman M. Gayevsky Anatoly P. Golovchenko Alexander V. Grishkun Evgeny V. Goodima Andrew О. Hurenko Artem O. Hushcha Tatiana О. Didiv Nataliya D. Demydchuk Bogdan A. Derevyanchuk Michael V. Zhirnov Viktor V. Zinchenko Hanna M. Zyabrev Volodymyr S. Karpets Leyla-Anastasiya М. Kachaeva Maryna V. Kachkovskyi Oleksiy D. Klyuchko Svitlana S. Kobzar Oleksandr L. Kozachenko Olexandr P. Kolesnikov Yaroslav S. Kolodiazhna Anastasiya O. Kolodiazhna Olga O. Kolodiazhnyi Oleg I. Kondratyuk Kostyantyn M. Kravets Volodymyr S. Kretynin Serhiy V. Kukuyev Maksym О. Kucher Oleksandr V. Mityukhin Оleg P. Mischenko Iryna M. Melnyk Andrii К. Merzhievskiy Danylo O. Mykula Mariya S. Moskvina Viktoria S. Mrug Galyna P. Muzychka Lyubov V. Muzychka Oxana V. Nikolayevska Valentyna І. Ocheretnyuk Alla D. Pilyo Stepan G. Panchyshyn Svitlana Ya. Pokotylo Igor V. Polovko Тetiana A. Popova Antonina V. Porhun Svitlana V. Prisyajnyuk Dmitry V. Prokopenko Volodumir M. Prostota Yaroslav A. Rentsevych Тetiana L. Synenko Vitaliy O. Slyvchuk Serhiy R. Smolii Oleg B. Solomiannyi Roman M. Sukhoveev Olexandr V. Tanchuk Vsevolod Yu. Trush Viacheslav V. Turov Кostyantyn V. Frasinyuk Mykhaylo S. Charochkina Larysa L. Chumachenko Svitlana A. Shablykin Оleg V. Shablykina Olga V. Shejko Sergij Y. Shulga Yrij V. Iakovenko Іgor N. Yaremchuk Iryna О. popup.nrat_date 2020-04-02 Close