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Information × Registration Number 0220U100122, 0118U003122 , R & D reports Title A development of methods of the new heteroalkenic derivatives synthesis by metathesis reactions. popup.stage_title Head Kashkovskiy Volodymyr I., Кандидат хімічних наук Registration Date 10-01-2020 Organization V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine popup.description2 Investigations of the synthesis of novel isooxazole derivatives and pyrimidine-2,4,6-trions, and the possibility of using ring-closing metathesis (RCM) reactions to obtain novel sulfonyldiamide isoxazole derivatives and heterocycloalkenyl spiro pyrimidine derivatives has been considered. Convenient production methods have been developed and synthesized a number of new symmetric diallylsulfonyl diamides of a number of isooxazole and derivatives of dibenzoylsubstituted trioxopyrimidine derivatives. A series of new isoxazole derivatives and a number of spirocyclic 1,3-dibenzoyl-substituted 5,5-diallylpyrimidine-2,4,6-trions have been synthesized by ring-closing metathesis reactions. The spectral and some physical characteristics of N, N-diallyl- (3-arylisooxazol-5-yl) -methylsulfonylamides and spirocyclic 1,3-dibenzoyl-substituted 5,5-diallylpyrimidine-2,4,6-trions were studied. N, N-diallyl- (3-arylisooxazol-5-yl) -methylsulfonylamides have been found to exhibit anti-wear activity when added to pentaerythritol oil. 1,3-dibenzoylsubstituted 5,5-diallylpyrimidine-2,4,6-trions have analgesic and antimicrobial effects. Product Description popup.authors Yevdokymenko Vitaly O. Aksylenko Maryna D. Bilenko Maryna A. Holovatiuk Volodymyr M. Dolia Lidia P. Zhuravel Yulia Yu. Kamenskyh Dmytro S. Kobyzhcha Nataliya I. Pavluik Oleksandr V. Reshetar Tamara P. Sukhoveev Volodymyr V. Tkachenko Tetiana V. Khimach Natalia Yu. Sheludko Yevgeniy V. popup.nrat_date 2020-04-02 Close